LES MALADIES TROPHOBLASTIQUES PDF

We'd like to understand how you use our websites in order to improve them. Register your interest. This retrospective study aimed at discussing epidemioclinical criteria and therapeutic results of persistent gestational trophoblastic disease PGTD and choriocarcinoma throughout a series of 26 patients treated between and We reviewed the epidemioclinical records of all the patients. After aspiration, pretherapeutic work-up, and hebdomadary dosage of plasmatic HCG, patients were divided into three prognostic groups according to the Gustave-Roussy Institute IGR classification hydatidiform mole, low-risk tumors, and high-risk tumors.

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We'd like to understand how you use our websites in order to improve them. Register your interest. This retrospective study aimed at discussing epidemioclinical criteria and therapeutic results of persistent gestational trophoblastic disease PGTD and choriocarcinoma throughout a series of 26 patients treated between and We reviewed the epidemioclinical records of all the patients.

After aspiration, pretherapeutic work-up, and hebdomadary dosage of plasmatic HCG, patients were divided into three prognostic groups according to the Gustave-Roussy Institute IGR classification hydatidiform mole, low-risk tumors, and high-risk tumors.

They were treated with different chemotherapy regimens: monodrug methotrexate therapy, AE protocol actinomycin and etoposid , and APE protocol actinomycin, etoposid, and cisplatinum adapted to each group. The mean age was 32 years extremes: 20 and Metrorragia and pelvic pain were themost frequent symptoms.

There were 20 cases of PGTD mole retention: three cases, invasive moles: 16 cases, and choriocarcinoma: one case and six primary choriocarcinomas. All the evaluable patients were cured with the first-line chemotherapy or after salvage chemotherapy in patients with considerable risk for the disease who showed a resistance to monodrug methotrexate therapy. We recorded two toxic deaths with APE protocol.

The epidemioclinical criteria did not have any particularity. We confirmed the effectiveness of chemotherapy in PTGD.

This is a preview of subscription content, log in to check access. Soper JT Gestational trophoblastic disease.

Obstet Gynecol — Contracept Fertil Sex — Bagshawe KD Choriocarcinoma. Rev Oncol — Google Scholar. Horn LC, Bilek K Clinicopathologic analysis of gestational trophoblastic disease: report of cases.

Gen Diagn Pathol —8. Am J Obstet Gynecol —5. Saunders, Philadelphia, p. Gynecol Oncol — Am J Obstet Gynecol — Gynecol Obstet Fertil —9.

Rev Prat — EMC, C — Gynecology — Philippe E, Dreyfus M Maladies trophoblastiques gestationnelles. Encycl Med Chir Obstet C 12p. Apropos of cases. A multivariate analysis. Cancer — Gynecol Obstet Fertil —8. Gynecologie —3. Download references. Correspondence to A. Khanfir, A. J Afr Cancer 2, 82—87 Download citation. Received : 27 April Accepted : 29 June Published : 01 February Issue Date : May Search SpringerLink Search. Abstract Objective This retrospective study aimed at discussing epidemioclinical criteria and therapeutic results of persistent gestational trophoblastic disease PGTD and choriocarcinoma throughout a series of 26 patients treated between and Patients and methods We reviewed the epidemioclinical records of all the patients.

Results The mean age was 32 years extremes: 20 and Conclusions The epidemioclinical criteria did not have any particularity. Encycl Med Chir Obstet C 12p Boudawara Authors A. Khanfir View author publications. You can also search for this author in PubMed Google Scholar.

View author publications. About this article Cite this article Khanfir, A.

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Diagnostic anatomopathologique des maladies trophoblastiques

Tumeurs trophoblastiques gestationnelles: aspects cliniques et radiologiques. Clinical and radiological features of gestational trophoblastic tumors. Gestational trophoblastic disease incorporates a group of diseases which differ from each other by their regressive evolution, their evolution to metastasis and to recurrence. It is a severe disease that affects women of childbearing age. Gestational trophoblastic tumors GTT are the malignant forms of gestational trophoblastic diseases.

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Maladies trophoblastiques gestationnelles persistantes: une étude de 26 cas

Gestational trophoblastic disease encompresses a group of interrelated diseases, following a pregnancy after a variable period of time. Hydatiform mole corresponds to premalignant disorders composed of villi with excess of paternal genetic material, with a malignant potential more important for complete mole than partial mole. Gestational trophoblastic neoplasia includes invasive mole, choriocarcinoma, placental site trophoblatic tumor and epithelioid trophoblastic tumor. Their histological diagnosis may be problematic on curettage material and needs to be correlated to serum hCG level and radiological findings. The use of chemotherapy has dramatically improved the prognosis of these lesions.

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