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Gene-expression brancched of good and poor prognosis were detected in different regions of the same tumor. Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development. Disclosures Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. Consider the following examples, but note that this is not an exhaustive list:. We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional analysis, and profiling of messenger RNA expression. Funded by the Medical Research Council and others.

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Gene-expression brancched of good and poor prognosis were detected in different regions of the same tumor. Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development. Disclosures Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality.

Consider the following examples, but note that this is not an exhaustive list:. We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional analysis, and profiling of messenger RNA expression. Funded by the Medical Research Council and others. Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors.

Find all citations in this journal default. Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor. Gerlinger, Marco et al. Provide sufficient details of any financial or non-financial competing interests to enable intratkmor to assess whether your comments might lead a reasonable person to bg your impartiality.

Recommend FPrime to your librarian or information manager to request an extended free trial for all users at your institution. METHODSTo examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and multirefion profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites.

Chemotherapy treatment is associated with altered PD-L1 expression in lung cancer patients Research output: Intratumor heterogeneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamycin mTOR kinase, correlating with S6 and 4EBP phosphorylation in vivo and constitutive activation of mTOR kinase activity in vitro. User comments must be in English, comprehensible and relevant to the article under discussion. Institutional access Recommend FPrime to your librarian or information manager to request an extended free trial for all users at your institution.

To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites. Intratumor heterogeneity, associated with heterogeneous protein function, may foster tumor adaptation and therapeutic failure through Darwinian selection.

Funding information This work was supported by: Good for Teaching 1. You are a close professional associate of any of the authors e. Consider the following examples, but note that this is not an exhaustive list: A summary of the content will be automatically included.

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