COMPRITOL 888 ATO PDF

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Based on its chemical composition, Compritol ATO is a blend of different esters of behenic acid with glycerol.

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Publication date Print : Jul-Sep Publisher: Medknow Publications. Keywords: Closed melt , compritol ATO , metformin , solid dispersion , solvent evaporation. Metformin hydrochloride MET sustained-release solid dispersions SD were prepared by the solvent evaporation and closed melt method, using compritol ATO as the polymer with five different drug-carrier ratios.

The formulated SD had acceptable physicochemical characters and SD with a 1 : 4 drug : Polymer ratio, which released the drug over an extended period of eight-to-ten hours. The data obtained from the in vitro release studies were fitted with various kinetic models and were found to follow the Korsmeyer-Peppas equation.

The prepared SD showed good stability over the studied time period. The solvent evaporation method was found to be more helpful than the closed melt method, giving the sustained release action. The SD with a 1 : 4 ratio of drug to polymer, by the solvent evaporation method, was selected as the most effective candidate for the subsequent development of a well-timed, sustained-release dosage form of the drug.

Data availability:. Keywords: compritol ato , solvent evaporation , closed melt , metformin , solid dispersion. Review article Invite someone to review. There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Publisher: Medknow Publications India. ISSN Print : ISSN Electronic : Address for correspondence: Dr: S. Jagdale; E-mail: jagdaleswati rediffmail. DOI: Subject: Pharmaceutics. Comment on this article Sign in to comment.

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Preparation and Characterization of Metformin Hydrochloride — Compritol 888 ATO Solid Dispersion

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Publication date Print : Jul-Sep Publisher: Medknow Publications. Keywords: Closed melt , compritol ATO , metformin , solid dispersion , solvent evaporation. Metformin hydrochloride MET sustained-release solid dispersions SD were prepared by the solvent evaporation and closed melt method, using compritol ATO as the polymer with five different drug-carrier ratios. The formulated SD had acceptable physicochemical characters and SD with a 1 : 4 drug : Polymer ratio, which released the drug over an extended period of eight-to-ten hours. The data obtained from the in vitro release studies were fitted with various kinetic models and were found to follow the Korsmeyer-Peppas equation.

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