Year , Volume 1 , Issue 3, Pages - Zotero Mendeley EndNote. Abstract en tr Atypical antipsychotics cause less frequently extrapyramidal system symptoms, neuroleptic malignant syndrome and hyperprolactinemia than typical antipsychotics. However hematological side effects such as leukopenia and neutropenia could occur during treatment with atypical antipsychotics.

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Objective: Although atypical antipsychotics are well-tolerated and effective treatment options for schizophrenia, they have metabolic side effects, including weight gain and increased risk of Type II Diabetes Mellitus DM.

Adiponectin, produced exclusively in adipocytes, is the most abundant serum adipokine. Low levels of adiponectin are correlated with DM, insulin resistance and coronary heart disease. Usage of atypical antipsychotics may create a risk of metabolic syndrome. The aim of this study was to evaluate the effects of antipsychotic usage on parameters related to development of metabolic syndrome. All patients had been treated with atypical antipsychotics for at least 3 months and were in remission.

Results: Serum adiponectin levels were significantly lower p Conclusion: Our findings supported the hypothesis that the length of administration of atypical antipsychotics has an effect on metabolic changes.

They also highlight the fact that when investigating metabolic changes generated by atypical antipsychotic effects, the length of time that the patient has been on the atypical antipsychotics should also be considered.

Keywords: Atypical antipsychotics; Metabolic syndrome; Serum adiponectin levels; Usage duration. Graph showing the correlation between the usage duration of atypical antipsychotics and adiponectin….

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See this image and copyright information in PMC. Similar articles Adjunctive effects of aripiprazole on metabolic profiles: comparison of patients treated with olanzapine to patients treated with other atypical antipsychotic drugs. Wang LJ, et al. Prog Neuropsychopharmacol Biol Psychiatry. Epub Oct PMID: Association of adiponectin and metabolic syndrome among patients taking atypical antipsychotics for schizophrenia: a cohort study.

Bai YM, et al. Schizophr Res. Epub May 5. The relationship between serum adiponectin levels, cardiometabolic indices and metabolic syndrome in schizophrenia. Tay YH, Lee J. Tay YH, et al. Asian J Psychiatr.

Epub Apr Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectin. Jin H, et al. Epub Jan Antipsychotic metabolic effects: weight gain, diabetes mellitus, and lipid abnormalities. McIntyre RS, et al. Can J Psychiatry. PMID: Review. Show more similar articles See all similar articles.

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Atypical Antipsychotics Induced Metabolic Syndrome/Atipik Antipsikotiklere Bagli Metabolik Sendrom




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