ANTIHYPERLIPIDEMIC DRUGS CLASSIFICATION PDF

Antihyperlipidemic agents promote reduction of lipid levels in the blood. Some antihyperlipidemic agents aim to lower the levels of low-density lipoprotein LDL cholesterol, some reduce triglyceride levels, and some help raise the high-density lipoprotein HDL cholesterol. By reducing the LDL cholesterol, they can prevent both the primary and secondary symptoms of coronary heart disease. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Atherosclerosis is the abnormal accumulation of lipids and products resulting from an inflammatory response in the walls of arteries, and is the leading cause of death in the Western world.

Heart attacks, angina pectoris, peripheral arterial disease, and strokes are common sequelae of atherosclerosis. In some cases, lowering serum lipid concentrations has been shown to prevent the sequelae of atherosclerosis and decrease mortality in patients with a history of cardiovascular disease and hyperlipidemia.

The five drug classes discussed in this chapter Figure 26—1 are used to decrease serum concentrations of lipids in the blood hyperlipidemia and to prevent or reverse associated atherosclerosis, or, in the case of hypertriglyceridemia, prevent pancreatitis. Although the drugs are generally safe and effective, adverse effects include drug—drug interactions and rare toxic reactions in skeletal muscle and the liver. The five classes of lipid-lowering drugs. These classes are based on the mechanisms of action of these drugs.

Lipids, mainly cholesterol and triglycerides, are transported in human plasma by macromolecular complexes termed lipoproteins. Lipoproteins are composed of a lipid core surrounded by apolipoproteins that regulate the uptake and off-loading of lipids and interactions with cell membrane receptors.

The lipoproteins that are primarily responsible for delivering cholesterol and triglycerides to peripheral tissues originate in the liver and contain a key apoprotein called B The uptake by cells of B—containing lipoproteins can occur by receptor-mediated endocytosis or by scavenger receptors. Receptor-mediated uptake is a carefully regulated process that protects cells from being overloaded with lipids.

In contrast, uptake by scavenger receptors is an unregulated process that can overwhelm the ability of a cell to sequester potentially toxic lipids safely.

Macrophages in arterial walls use scavenger receptors to take up circulating lipoproteins, especially particles with apolipoproteins that have been modified by free radicals. When these macrophages become overloaded with lipids, they are transformed into distressed foam cells that initiate a local inflammatory response.

Engorged foam cells, foam cells that have burst, and the products of the inflammatory responses form the core of an atherosclerotic plaque. Whereas plaques can slowly occlude coronary and cerebral vessels, clinical symptoms are more frequently precipitated by rupture of unstable plaques, leading to occlusive thrombi. Schematic diagram of lipoprotein handling by hepatocytes. The sites of action of several antihyperlipidemic drugs are shown.

For identification of abbreviations of the lipoproteins, some drug classes, and additional discussion, see text. Another lipoprotein, high-density lipoprotein HDL , exerts several antiatherogenic effects. HDL participates in pathways that retrieve cholesterol from the artery wall and inhibit the oxidation of atherogenic lipoproteins. Forgot Password? What is MyAccess? Otherwise it is hidden from view. Forgot Username? About MyAccess If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

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Panus P. Peter C. Panus, et al. Accessed June 05, MLA Citation. Download citation file: RIS Zotero. Reference Manager. Autosuggest Results. Figure 26—1.

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GRUNDFOS UPS 15-50 MANUAL PDF

Antihyperlipidemic agents

This course will review the normal biological functions of lipids and differentiate lipoprotein types based on their structure and function. While this presentation will provide a brief review of all lipid types, there will be a focus on cholesterol and associated disease states, medications, and implications for laboratory testing. This course is also appropriate for medical laboratory science students, pathology residents, and other healthcare personnel who are responsible for prescribing and administering antihyperlipidemic medications. Author information : Kyle D. He is currently pursuing residency in internal medicine at the University of Louisville in Louisville, Kentucky. Before attending medical school, Dr.

EVALUATING AND HEDGING EXOTIC SWAP INSTRUMENTS VIA LGM PDF

Lipid-lowering agent

If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Atherosclerosis is the abnormal accumulation of lipids and products resulting from an inflammatory response in the walls of arteries, and is the leading cause of death in the Western world. Heart attacks, angina pectoris, peripheral arterial disease, and strokes are common sequelae of atherosclerosis. In some cases, lowering serum lipid concentrations has been shown to prevent the sequelae of atherosclerosis and decrease mortality in patients with a history of cardiovascular disease and hyperlipidemia. The five drug classes discussed in this chapter Figure 26—1 are used to decrease serum concentrations of lipids in the blood hyperlipidemia and to prevent or reverse associated atherosclerosis, or, in the case of hypertriglyceridemia, prevent pancreatitis. Although the drugs are generally safe and effective, adverse effects include drug—drug interactions and rare toxic reactions in skeletal muscle and the liver.

EWON 2005 CD PDF

Antihyperlipidemic Agents

Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website. See our User Agreement and Privacy Policy. See our Privacy Policy and User Agreement for details. Published on Mar 13, It gives a description of anti hyperlipidemics with their medicinal chemistry.

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